Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Metabolic waypoints during T cell differentiation.

Wilfahrt, Drew; Delgoffe, Greg M.

Nat Immunol ; 25(2): 206-217, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38238609

2.

Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity.

Vignali, Paolo D A; DePeaux, Kristin; Watson, McLane J; Ye, Chenxian; Ford, B Rhodes; Lontos, Konstantinos; McGaa, Nicole K; Scharping, Nicole E; Menk, Ashley V; Robson, Simon C; Poholek, Amanda C; Rivadeneira, Dayana B; Delgoffe, Greg M.

Nat Immunol ; 24(2): 267-279, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36543958

3.

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion.

Scharping, Nicole E; Rivadeneira, Dayana B; Menk, Ashley V; Vignali, Paolo D A; Ford, B Rhodes; Rittenhouse, Natalie L; Peralta, Ronal; Wang, Yiyang; Wang, Yupeng; DePeaux, Kristin; Poholek, Amanda C; Delgoffe, Greg M.

Nat Immunol ; 22(2): 205-215, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33398183

4.

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis.

Weisel, Florian J; Mullett, Steven J; Elsner, Rebecca A; Menk, Ashley V; Trivedi, Nikita; Luo, Wei; Wikenheiser, Daniel; Hawse, William F; Chikina, Maria; Smita, Shuchi; Conter, Laura J; Joachim, Stephen M; Wendell, Stacy G; Jurczak, Michael J; Winkler, Thomas H; Delgoffe, Greg M; Shlomchik, Mark J.

Nat Immunol ; 21(3): 331-342, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-32066950

5.

Interferon-Î³ Drives T_reg Fragility to Promote Anti-tumor Immunity.

Overacre-Delgoffe, Abigail E; Chikina, Maria; Dadey, Rebekah E; Yano, Hiroshi; Brunazzi, Erin A; Shayan, Gulidanna; Horne, William; Moskovitz, Jessica M; Kolls, Jay K; Sander, Cindy; Shuai, Yongli; Normolle, Daniel P; Kirkwood, John M; Ferris, Robert L; Delgoffe, Greg M; Bruno, Tullia C; Workman, Creg J; Vignali, Dario A A.

Cell ; 169(6): 1130-1141.e11, 2017 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-28552348

6.

IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival.

Majumder, Saikat; Amatya, Nilesh; Revu, Shankar; Jawale, Chetan V; Wu, Dongwen; Rittenhouse, Natalie; Menk, Ashley; Kupul, Saran; Du, Fang; Raphael, Itay; Bhattacharjee, Amrita; Siebenlist, Ulrich; Hand, Timothy W; Delgoffe, Greg M; Poholek, Amanda C; Gaffen, Sarah L; Biswas, Partha S; McGeachy, Mandy J.

Nat Immunol ; 20(5): 534-545, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30962593

7.

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.

Pollizzi, Kristen N; Sun, Im-Hong; Patel, Chirag H; Lo, Ying-Chun; Oh, Min-Hee; Waickman, Adam T; Tam, Ada J; Blosser, Richard L; Wen, Jiayu; Delgoffe, Greg M; Powell, Jonathan D.

Nat Immunol ; 17(6): 704-11, 2016 06.

Artigo em Inglês | MEDLINE | ID: mdl-27064374

8.

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance.

Rivadeneira, Dayana B; DePeaux, Kristin; Wang, Yiyang; Kulkarni, Aditi; Tabib, Tracy; Menk, Ashley V; Sampath, Padmavathi; Lafyatis, Robert; Ferris, Robert L; Sarkar, Saumendra N; Thorne, Stephen H; Delgoffe, Greg M.

Immunity ; 51(3): 548-560.e4, 2019 09 17.

Artigo em Inglês | MEDLINE | ID: mdl-31471106

9.

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8⁺ T Cell-Derived Interferon-Î³.

Liu, Chang; Chikina, Maria; Deshpande, Rahul; Menk, Ashley V; Wang, Ting; Tabib, Tracy; Brunazzi, Erin A; Vignali, Kate M; Sun, Ming; Stolz, Donna B; Lafyatis, Robert A; Chen, Wei; Delgoffe, Greg M; Workman, Creg J; Wendell, Stacy G; Vignali, Dario A A.

Immunity ; 51(2): 381-397.e6, 2019 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-31350177

10.

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

Watson, McLane J; Vignali, Paolo D A; Mullett, Steven J; Overacre-Delgoffe, Abigail E; Peralta, Ronal M; Grebinoski, Stephanie; Menk, Ashley V; Rittenhouse, Natalie L; DePeaux, Kristin; Whetstone, Ryan D; Vignali, Dario A A; Hand, Timothy W; Poholek, Amanda C; Morrison, Brett M; Rothstein, Jeffrey D; Wendell, Stacy G; Delgoffe, Greg M.

Nature ; 591(7851): 645-651, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33589820

11.

CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours.

Zappasodi, Roberta; Serganova, Inna; Cohen, Ivan J; Maeda, Masatomo; Shindo, Masahiro; Senbabaoglu, Yasin; Watson, McLane J; Leftin, Avigdor; Maniyar, Rachana; Verma, Svena; Lubin, Matthew; Ko, Myat; Mane, Mayuresh M; Zhong, Hong; Liu, Cailian; Ghosh, Arnab; Abu-Akeel, Mohsen; Ackerstaff, Ellen; Koutcher, Jason A; Ho, Ping-Chih; Delgoffe, Greg M; Blasberg, Ronald; Wolchok, Jedd D; Merghoub, Taha.

Nature ; 591(7851): 652-658, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33588426

12.

Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection.

Carreno-Florez, Grace P; Kocak, Brian R; Hendricks, Matthew R; Melvin, Jeffrey A; Mar, Katrina B; Kosanovich, Jessica; Cumberland, Rachel L; Delgoffe, Greg M; Shiva, Sruti; Empey, Kerry M; Schoggins, John W; Bomberger, Jennifer M.

PLoS Pathog ; 19(11): e1011719, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37939149

13.

VHL Brings Warburg into the Memory Spotlight.

Delgoffe, Greg M.

Immunity ; 45(5): 953-955, 2016 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-27851921

14.

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Scharping, Nicole E; Menk, Ashley V; Moreci, Rebecca S; Whetstone, Ryan D; Dadey, Rebekah E; Watkins, Simon C; Ferris, Robert L; Delgoffe, Greg M.

Immunity ; 45(2): 374-88, 2016 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-27496732

15.

Interleukin-35 Limits Anti-Tumor Immunity.

Turnis, Meghan E; Sawant, Deepali V; Szymczak-Workman, Andrea L; Andrews, Lawrence P; Delgoffe, Greg M; Yano, Hiroshi; Beres, Amy J; Vogel, Peter; Workman, Creg J; Vignali, Dario A A.

Immunity ; 44(2): 316-29, 2016 Feb 16.

Artigo em Inglês | MEDLINE | ID: mdl-26872697

16.

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion.

Bengsch, Bertram; Johnson, Andy L; Kurachi, Makoto; Odorizzi, Pamela M; Pauken, Kristen E; Attanasio, John; Stelekati, Erietta; McLane, Laura M; Paley, Michael A; Delgoffe, Greg M; Wherry, E John.

Immunity ; 45(2): 358-73, 2016 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-27496729

17.

Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet.

Zhao, Steven; Peralta, Ronal M; Avina-Ochoa, Natalia; Delgoffe, Greg M; Kaech, Susan M.

Semin Immunol ; 52: 101485, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-34462190

18.

Hypoxia Reduction Sensitizes Refractory Cancers to Immunotherapy.

Jayaprakash, Priyamvada; Vignali, Paolo Dario Angelo; Delgoffe, Greg M; Curran, Michael A.

Annu Rev Med ; 73: 251-265, 2022 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-34699264

19.

The composition and signaling of the IL-35 receptor are unconventional.

Collison, Lauren W; Delgoffe, Greg M; Guy, Clifford S; Vignali, Kate M; Chaturvedi, Vandana; Fairweather, DeLisa; Satoskar, Abhay R; Garcia, K Christopher; Hunter, Christopher A; Drake, Charles G; Murray, Peter J; Vignali, Dario A A.

Nat Immunol ; 13(3): 290-9, 2012 Feb 05.

Artigo em Inglês | MEDLINE | ID: mdl-22306691

20.

PP2A's restraint of mTOR is critical for T(reg) cell activity.